How Molecular Crowding Differs from Macromolecular Crowding: A Femtosecond Mid-Infrared Pump–Probe Study

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Title
How Molecular Crowding Differs from Macromolecular Crowding: A Femtosecond Mid-Infrared Pump–Probe Study
Author(s)
Pramod Kumar Verma; Achintya Kundu; Minhaeng Cho
Publication Date
2018-11
Journal
Journal of Physical Chemistry Letters, v.9, no.22, pp.6584 - 6592
Publisher
AMER CHEMICAL SOC
Abstract
Crowding is an inherent property of living systems in which biochemical processes occur in highly concentrated solutions of various finite-sized species of both low (molecular crowding) and high (macromolecular crowding) molecular weights. Is molecular crowding fundamentally different from macromolecular crowding? To answer this question, we use a femtosecond mid-infrared pump–probe technique with three vibrational probes in molecular (diethylene glycol) and macromolecular (polyethylene glycol) solutions. In less crowded media, both molecular and macromolecular crowders fail to affect the dynamics of interstitial bulk-like water molecules and those at the crowder/water interface. In highly crowded media, interstitial water dynamics strongly depends on molecular crowding, but macromolecular crowding does not alter the bulk-like hydration dynamics and has a modest crowding effect on water at the crowder/water interface. The results of this study provide a molecular level understanding of the structural and dynamic changes to water and the water-mediated cross-linking of crowders. © 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/5077
ISSN
1948-7185
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
Files in This Item:
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