Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy

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Title
Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy
Author(s)
Seonghun Kang; Yu Lim Hong; Bon-Cheol Ku; Seunghyun Lee; Seomgwoo Ryu; Dal-hee Min; Hongje Jang; Young-kwan Kim
Publication Date
2018-11
Journal
NANOTECHNOLOGY, v.29, no.47, pp.475604 -
Publisher
IOP PUBLISHING LTD
Abstract
A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities. © 2018 IOP Publishing Ltd Printed in the UK
URI
https://pr.ibs.re.kr/handle/8788114/5070
ISSN
0957-4484
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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