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면역미생물공생연구단
면역 미생물 공생 연구단
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Inflammation-induced Id2 promotes plasticity in regulatory T cells

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Title
Inflammation-induced Id2 promotes plasticity in regulatory T cells
Author(s)
Sung-Min Hwang; Garima Sharma; Ravi Verma; Seohyun Byun; Dipayan Rudra; Sin-Hyeog Im
Publication Date
2018-11
Journal
Nature Communications, v.9, no.1, pp.4736 -
Publisher
NATURE PUBLISHING GROUP
Abstract
TH17 cells originating from regulatory T (Treg) cells upon loss of the Treg-specific transcription factor Foxp3 accumulate in sites of inflammation and aggravate autoimmune diseases. Whether an active mechanism drives the generation of these pathogenic ��ex-Foxp3 TH17�� cells, remains unclear. Here we show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of Treg into ex-Foxp3 TH17 cells. Expression of Id2 in in vitro differentiated iTreg cells reduces the expression of Foxp3 by sequestration of the transcription activator E2A, leading to the induction of TH17-related cytokines. Treg-specific ectopic expression of Id2 in mice significantly reduces the Treg compartment and causes immune dysregulation. Cellular fate-mapping experiments reveal enhanced Treg plasticity compared to wild-type, resulting in exacerbated experimental autoimmune encephalomyelitis pathogenesis or enhanced anti-tumor immunity. Our findings suggest that controlling Id2 expression may provide a novel approach for effective Treg cell immunotherapies for both autoimmunity and cancer. (C) 2018, The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/5056
ISSN
2041-1723
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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