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Microsphere-based interferometric optical probe

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Title
Microsphere-based interferometric optical probe
Author(s)
Yongjae Jo; Junhwan Kwon; Moonseok Kim; Wonshik Choi; Myunghwan Choi
Publication Date
2018-11
Journal
Nature Communications, v.9, no.1, pp.4577 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Fluorescent optical probes have rapidly transformed our understanding of complex biological systems by providing specific information on biological targets in the natural living state. However, their utility is often limited by insufficient brightness, photostability, and multiplexing capacity. Here, we report a conceptually new optical probe, termed ‘reflectophore’, which is based on the spectral interference from a dielectric microsphere. Reflectophores are orders-of-magnitudes brighter than conventional fluorophores and are free from photobleaching, enabling practically unlimited readout at high fidelity. They also offer high-degree multiplexing, encoded in their optical size, which can be readily decoded through interferometric detection with nanoscale accuracy, even in turbid biological media. Furthermore, we showcase their biological applications in cellular barcoding and microenvironmental sensing of a target protein and local electric field. © The Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/5046
ISSN
2041-1723
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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