Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

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Title
Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system
Author(s)
Jeon, H; Jihoon Kim; Yeong Mi Lee; Jinhwan Kim; Hyung Woo Choi; Junseok Lee; Park, H; Kang, Y; Kim, IS; Lee, BH; Hoffman, AS; Won Jong Kim
Publication Date
2016-06
Journal
JOURNAL OF CONTROLLED RELEASE, v.231, no., pp.68 - 76
Publisher
ELSEVIER SCIENCE BV
Abstract
This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, beta-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between beta-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems. (C) 2016 Elsevier B.V. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/5021
ISSN
0168-3659
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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