Efficient Syntheses of Diverse, Medicinally Relevant Targets Planned by Computer and Executed in the Laboratory Highly Cited Paper

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Title
Efficient Syntheses of Diverse, Medicinally Relevant Targets Planned by Computer and Executed in the Laboratory
Author(s)
Tomasz Klucznik; Barbara Mikulak-Klucznik; Michael P.McCormack; Heather Lima; Sara Szymkuć; Manishabrata Bhowmick; Karol Molga; Yubai Zhou; Lindsey Rickershauser; Ewa P.Gajewska; Alexei Toutchkine; Piotr Dittwald; Michał P.Startek; Gregory J.Kirkovits; Rafał Roszak; Ariel Adamski; Bianka Sieredzińska; Milan Mrksich; Sarah L.J.Trice; Bartosz A.Grzybowski
Publication Date
2018-03
Journal
CHEM, v.4, no.3, pp.522 - 532
Publisher
CELL PRESS
Abstract
The Chematica program was used to autonomously design synthetic pathways to eight structurally diverse targets, including seven commercially valuable bioactive substances and one natural product. All of these computer-planned routes were successfully executed in the laboratory and offer significant yield improvements and cost savings over previous approaches, provide alternatives to patented routes, or produce targets that were not synthesized previously © 2018 The Authors. Published by Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/5005
ISSN
2451-9294
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
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