A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery

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Title
A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery
Author(s)
Kyeng Min Park; Hyunuk Kim; James Murray; Jaehyoung Koo; Kimoon Kim
Publication Date
2017
Journal
SUPRAMOLECULAR CHEMISTRY, v.29, no.6, pp.441 - 445
Publisher
TAYLOR & FRANCIS LTD
Abstract
Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications. © 2016 Informa UK Limited, trading as Taylor & Francis Group
URI
https://pr.ibs.re.kr/handle/8788114/4824
ISSN
1061-0278
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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