Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation

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Title
Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation
Author(s)
Seokhwan Yun; Tae-Hyun Shin; Jae-Hyun Lee; Mi Hyeon Cho; Il-Sun Kim; Ji-wook Kim; Kwangsoo Jung; Il-Shin Lee; Jinwoo Cheon; Kook In Park
Publication Date
2018-02
Journal
NANO LETTERS, v.18, no.2, pp.838 - 845
Publisher
AMER CHEMICAL SOC
Abstract
Cell-based therapies are attractive for treating various degenerative disorders and cancer but delivering functional cells to the region of interest in vivo remains difficult. The problem is exacerbated in dense biological matrices such as solid tissues because these environments impose significant steric hindrances for cell movement. Here, we show that neural stem cells transfected with zinc-doped ferrite magnetic nanoparticles (ZnMNPs) can be pulled by an external magnet to migrate to the desired location in the brain. These magnetically labeled cells (Mag-Cells) can migrate because ZnMNPs generate sufficiently strong mechanical forces to overcome steric hindrances in the brain tissues. Once at the site of lesion, Mag-Cells show enhanced neuronal differentiation and greater secretion of neurotrophic factors than unlabeled control stem cells. Our study shows that ZnMNPs activate zinc-mediated Wnt signaling to facilitate neuronal differentiation. When implemented in a rodent brain stroke model, Mag-Cells led to significant recovery of locomotor performance in the impaired limbs of the animals. Our findings provide a simple magnetic method for controlling migration of stem cells with high therapeutic functions, offering a valuable tool for other cell-based therapies. © 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4680
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
Files in This Item:
25.Nano Letters 18, 838-845, (2018).pdfDownload

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