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Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits

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Title
Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits
Author(s)
Bistra lordanova; Alberto Vazquez; Takashi DY Kozai; Mitsuhiro Fukuda; Seong-Gi Kim
Publication Date
2018-04
Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.38, no.4, pp.627 - 640
Publisher
NATURE PUBLISHING GROUP
Abstract
The interhemispheric circuit connecting the left and the right mammalian brain plays a key role in integration of signals from the left and the right side of the body. The information transfer is carried out by modulation of simultaneous excitation and inhibition. Hemodynamic studies of this circuit are inconsistent since little is known about neurovascular coupling of mixed excitatory and inhibitory signals. We investigated the variability in hemodynamic responses driven by the interhemispheric circuit during optogenetic and somatosensory activation. We observed differences in the neurovascular response based on the stimulation site – cell bodies versus distal projections. In half of the experiments, optogenetic stimulation of the cell bodies evoked a predominant post-synaptic inhibition in the other hemisphere, accompanied by metabolic oxygen consumption without coupled functional hyperemia. When the same transcallosal stimulation resulted in predominant post-synaptic excitation, the hemodynamic response was biphasic, consisting of metabolic dip followed by functional hyperemia. Optogenetic suppression of the postsynaptic excitation abolished the coupled functional hyperemia. In contrast, light stimulation at distal projections evoked consistently a metabolic response. Our findings suggest that functional hyperemia requires signals originating from the cell body and the hemodynamic response variability appears to reflect the balance between the post-synaptic excitation and inhibition.(2018 Journal of Cerebral Blood Flow &Metabolism) (c) Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/4584
ISSN
0271-678X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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