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나노의학 연구단
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Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets

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Title
Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets
Author(s)
Jin-sil Choi; Soojin Kim; Dongwon Yoo; Tae-Hyun Shin; Hoyoung Kim; Muller D. Gomes; Sun Hee Kim; Alexander Pines; Jinwoo Cheon
Publication Date
2017-05
Journal
NATURE MATERIALS, v.16, no.5, pp.537 - 542
Publisher
NATURE PUBLISHING GROUP
Abstract
Nanoscale distance-dependent phenomena, such as Förster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems1–4. Here, we report a new type of magnetism-based nanoscale distancedependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets.We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic ‘enhancer’ and a superparamagnetic ‘quencher’, where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/4249
ISSN
1476-1122
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
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