Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

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Title
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles
Author(s)
Min, C; Park, J; Mun, JK; Yongjun Lim; Min, J; Lim, JW; Kang, DM; Ahn, HK; Tae-Hyun Shin; Jinwoo Cheon; Lee, HS; Weissleder, R; Castro, CM; Hakho Lee
Publication Date
2017-12
Journal
LAB ON A CHIP, v.17, no.23, pp.4000 - 4007
Publisher
ROYAL SOC CHEMISTRY
Abstract
Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (similar to 10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells. © The Royal Society of Chemistry 2017
URI
https://pr.ibs.re.kr/handle/8788114/4224
ISSN
1473-0197
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
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