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Orlando Scharer
유전체 항상성 연구단
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ERCC1-XPF endonuclease-positioned to cut

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Title
ERCC1-XPF endonuclease-positioned to cut
Author(s)
Orlando D Scharer
Publication Date
2017-07
Journal
EMBO JOURNAL, v.36, no.14, pp.1993 - 1995
Publisher
WILEY
Abstract
To counteract damage to our genomes, numerous endo-and exonucleases incise the DNA backbone to remove damaged and aberrant DNA structures. It is imperative that such incisions be very tightly controlled, as unwanted DNA breaks are a key source of genome instability. Two new papers in The EMBO Journal shed light on how the activity of one such nuclease-ERCC1-XPF, an enzyme involved in various DNA repair pathways-is regulated to perform incision in the vicinity of DNA interstrand crosslinks. (c) 2017 The Author
URI
https://pr.ibs.re.kr/handle/8788114/4154
ISSN
0261-4189
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
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