High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering

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Title
High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering
Author(s)
Sungsam Kang; Pilsung Kang; Seungwon Jeong; Yongwoo Kwon; Taeseok D. Yang; Jin Hee Hong; Moonseok Kim; Kyung-Deok Song; Jin Hyoung Park; Jun Ho Lee; Myoung Joon Kim; Ki Hean Kim; Wonshik Choi
Publication Date
2017-12
Journal
NATURE COMMUNICATIONS, v.8, no.1, pp.2157 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Thick biological tissues give rise to not only the multiple scattering of incoming light waves, but also the aberrations of remaining signal waves. The challenge for existing optical microscopy methods to overcome both problems simultaneously has limited sub-micron spatial resolution imaging to shallow depths. Here we present an optical coherence imaging method that can identify aberrations of waves incident to and reflected from the samples separately, and eliminate such aberrations even in the presence of multiple light scattering. The proposed method records the time-gated complex-field maps of backscattered waves over various illumination channels, and performs a closed-loop optimization of signal waves for both forward and phase-conjugation processes. We demonstrated the enhancement of the Strehl ratio by more than 500 times, an order of magnitude or more improvement over conventional adaptive optics, and achieved a spatial resolution of 600 nm up to an imaging depth of seven scattering mean free paths. © The Author(s) 2017
URI
https://pr.ibs.re.kr/handle/8788114/4119
ISSN
2041-1723
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
Files in This Item:
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