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Andrographolide-loaded polymerized phenylboronic acid nanoconstruct for stimuli-responsive chemotherapy

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Title
Andrographolide-loaded polymerized phenylboronic acid nanoconstruct for stimuli-responsive chemotherapy
Author(s)
Jinhwan Kim; Junseok Lee; Yeong Mi Lee; Swapan Pramanick; Sooseok Im; Won Jong Kim
Publication Date
2017-08
Journal
JOURNAL OF CONTROLLED RELEASE, v.259, no., pp.203 - 211
Publisher
ELSEVIER SCIENCE BV
Abstract
Along with the successful discovery of paclitaxel as an anticancer drug, natural products have drawn great attention in drug discovery. Recently, andrographolide (AND) from Andrographis paniculata was reported to provide several benefits, including an anticancer effect. However, the extremely low solubility of the compound in an aqueous medium was an obstacle to overcome for the systemic administration and clinical application of AND. Based on our previous report, we formulated a water-soluble nanoconstruct by forming a boronic ester between the cis-1,3-diol of AND with hydrophilically polymerized phenylboronic acid (pPBA). The release of loaded AND was controlled by intracellular conditions, specifically, by low pH and high ATP concentrations, due to the pH- and diol-dependent affinity of the boronic ester. Because of the intrinsic property of the PBA moiety, the pPBA-AND nanoconstruct exhibited an excellent tumor targeting ability both in vitro and in vivo. Finally, a significant inhibition of tumor growth was observed in vivo. Taken together, our strategy, which is based on the formulation of a soluble nanoconstruct using hydrophilically polymerized PBA and a cis-diol, is plausible and provides a delivery system for a wide variety of chemotherapeutics. This strategy has applications not only in cancer therapy but also broader fields such as anti-inflammation or immunotherapy. (C) 2016 Elsevier B.V. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/3877
ISSN
0168-3659
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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