BROWSE

Related Scientist

Researcher

뇌과학이미징연구단
뇌과학 이미징 연구단
more info

Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection

Cited 0 time in webofscience Cited 0 time in scopus
78 Viewed 3 Downloaded
Title
Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection
Author(s)
Leonie Koban; Ethan Kross; Choong-Wan Woo; Luka Ruzic; Tor D. Wager
Publication Date
2017-03
Journal
JOURNAL OF NEUROSCIENCE, v.37, no.13, pp.3621 - 3631
Publisher
SOC NEUROSCIENCE
Abstract
Placebo treatments can strongly affect clinical outcomes, but research on how they shape other life experiences and emotional well-being is in its infancy. We used fMRI in humans to examine placebo effects on a particularly impactful life experience, social pain elicited by a recent romantic rejection. We compared these effects with placebo effects on physical (heat) pain, which are thought to depend on pathways connecting prefrontal cortex and periaqueductal gray (PAG). Placebo treatment, compared with control, reduced both social and physical pain, and increased activity in the dorsolateral prefrontal cortex (dlPFC) in both modalities. Placebo further altered the relationship between affect and both dlPFC and PAG activity during social pain, and effects on behavior were mediated by a pathway connecting dlPFC to the PAG, building on recent work implicating opioidergic PAG activity in the regulation of social pain. These findings suggest that placebo treatments reduce emotional distress by altering affective representations in frontal-brainstem systems. Copyright©2017 the authors
URI
https://pr.ibs.re.kr/handle/8788114/3754
ISSN
0270-6474
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
08_우충완_Frontal-brainstem pathways mediating placebo...pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse