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뇌과학이미징연구단
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Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection

DC Field Value Language
dc.contributor.authorLeonie Koban-
dc.contributor.authorEthan Kross-
dc.contributor.authorChoong-Wan Woo-
dc.contributor.authorLuka Ruzic-
dc.contributor.authorTor D. Wager-
dc.date.available2017-09-05T05:28:52Z-
dc.date.created2017-04-24-
dc.date.issued2017-03-
dc.identifier.issn0270-6474-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3754-
dc.description.abstractPlacebo treatments can strongly affect clinical outcomes, but research on how they shape other life experiences and emotional well-being is in its infancy. We used fMRI in humans to examine placebo effects on a particularly impactful life experience, social pain elicited by a recent romantic rejection. We compared these effects with placebo effects on physical (heat) pain, which are thought to depend on pathways connecting prefrontal cortex and periaqueductal gray (PAG). Placebo treatment, compared with control, reduced both social and physical pain, and increased activity in the dorsolateral prefrontal cortex (dlPFC) in both modalities. Placebo further altered the relationship between affect and both dlPFC and PAG activity during social pain, and effects on behavior were mediated by a pathway connecting dlPFC to the PAG, building on recent work implicating opioidergic PAG activity in the regulation of social pain. These findings suggest that placebo treatments reduce emotional distress by altering affective representations in frontal-brainstem systems. Copyright©2017 the authors-
dc.description.uri1-
dc.language영어-
dc.publisherSOC NEUROSCIENCE-
dc.subjectemotion regulation-
dc.subjectnociception-
dc.subjectopioid-
dc.subjectplacebo-
dc.subjectresilience-
dc.subjectsocial-
dc.titleFrontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000397823700017-
dc.identifier.scopusid2-s2.0-85016520654-
dc.identifier.rimsid59181ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorChoong-Wan Woo-
dc.identifier.doi10.1523/JNEUROSCI.2658-16.2017-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSCIENCE, v.37, no.13, pp.3621 - 3631-
dc.citation.titleJOURNAL OF NEUROSCIENCE-
dc.citation.volume37-
dc.citation.number13-
dc.citation.startPage3621-
dc.citation.endPage3631-
dc.date.scptcdate2018-10-01-
dc.description.scptc1-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusPERIAQUEDUCTAL GRAY-
dc.subject.keywordPlusPHYSICAL PAIN-
dc.subject.keywordPlusNEURAL REPRESENTATIONS-
dc.subject.keywordPlusINDIVIDUAL-DIFFERENCES-
dc.subject.keywordPlusEMOTION REGULATION-
dc.subject.keywordPlusOPIOID SYSTEM-
dc.subject.keywordPlusANALGESIA-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusMODULATION-
dc.subject.keywordAuthoremotion regulation-
dc.subject.keywordAuthornociception-
dc.subject.keywordAuthoropioid-
dc.subject.keywordAuthorplacebo-
dc.subject.keywordAuthorresilience-
dc.subject.keywordAuthorsocial-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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