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Bahiru Punja Benke
복잡계 자기조립 연구단
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Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages

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Title
Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
Author(s)
Bahiru Punja Benke; Pulakesh Aich; Younghoon Kim; Kyung Lock Kim; Md Rumum Rohman; Soonsang Hong; In-Chul Hwang; Eun Hui Lee; Joon Ho Roh; Kimoon Kim
Publication Date
2017-06
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.139, no.22, pp.7432 - 7435
Publisher
AMER CHEMICAL SOC
Abstract
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/3669
ISSN
0002-7863
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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