Studying Water Hydrogen-Bonding Network near the Lipid Multibilayer with Multiple IR Probes

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Title
Studying Water Hydrogen-Bonding Network near the Lipid Multibilayer with Multiple IR Probes
Author(s)
Achintya Kundu; Pramod Kumar Verma; Jeong-Hyon Ha; Minhaeng Cho
Publication Date
2017-02
Journal
JOURNAL OF PHYSICAL CHEMISTRY A, v.121, no.7, pp.1435 - 1441
Publisher
AMER CHEMICAL SOC
Abstract
A critical difference between living and nonliving is the existence of cell membranes, and hydration of membrane surface is a prerequisite for structural stability and various functions such as absorption/desorption of drugs, proteins, and ions. Therefore, a molecular level understanding of water structure and dynamics near the membrane is important to perceive the role of water in such a biologically relevant environment. In our recent paper [ J. Phys. Chem. Lett. 2016, 7, 741] on the IR pump–probe study of the OD stretch mode of HDO near lipid multibilayers, we have observed two different vibrational lifetime components of OD stretch mode in the phospholipid multibilayer systems. The faster component (0.6 ps) is associated with OD groups interacting with the phosphate moiety of the lipid, while the slower component (1.9 ps) is due to choline-associated water molecules that are close to bulklike water. Here, we additionally use hydrazoic acid (HN3) as another IR probe of which frequency is highly sensitive to its local H-bonding water density. Interestingly, we found that the vibrational lifetime of the asymmetric azido stretch mode of HN3 in the lipid multibilayer system is similar to that in neat water, whereas its orientational relaxation is a bit slower than that in bulk water. This indicates that due to the tight packing of lipid molecules, particularly the head parts, in the gel phase, HN3 molecules mostly stay near the choline group of lipid and interact with water molecules in the vicinity of choline groups. This suggests that membrane surface-adsorbed molecules such as hydrophilic drug molecules may interact with choline-associated water molecules, when the membrane is in the gel phase, instead of phosphate-associated water molecules. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/3598
ISSN
1089-5639
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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