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복잡계 자기조립 연구단
복잡계 자기조립 연구단
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Remission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligand

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dc.contributor.authorDonghyun Jangko
dc.contributor.authorYeong Mi Leeko
dc.contributor.authorLee J.ko
dc.contributor.authorDoh J.ko
dc.contributor.authorWon Jong Kimko
dc.date.available2017-03-22T01:53:51Z-
dc.date.created2017-02-24ko
dc.date.issued201701ko
dc.identifier.issn2045-2322ko
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/3378ko
dc.description.abstractA polyrotaxane-based nanoconstruct with pliable structure carrying a chemotherapeutic drug was developed for targeting circulating lymphoblastic leukaemia cells in a fluidic environment of blood vessels in vivo. By introducing lymphoblast targeting aptamer DNA through cyclodextrin, threaded in poly(ethylene glycol) as polyrotaxane, target aptamer slides along the long polymeric chain and actively search for target ligand, leading to active targeting in dynamic fluidic system which is enhanced by up to 6-fold compared with that of control carriers with non-sliding targeting ligands. Moreover, the drug carrier was made stimuli-responsive by employing i-motif DNA to selective releases of its payload at intracellular acidic condition. These combined features resulted in the effective remission of lymphoblastic leukaemia both in vitro and in dynamic blood vessels in vivo. © The Author(s) 2017ko
dc.languageENGko
dc.publisherNATURE PUBLISHING GROUPko
dc.titleRemission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligandko
dc.typeARTICLEko
dc.type.rimsAko
dc.identifier.wosid000391933900001ko
dc.identifier.scopusid2-s2.0-85009833784ko
dc.identifier.pid347null
dc.identifier.pid907null
dc.identifier.pid384null
dc.description.wostc3-
dc.date.scptcdate2018-10-01-
dc.identifier.doi10.1038/srep40739ko
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.7, no., pp.40739 -ko
dc.date.tcdate2018-10-01-
dc.description.scptc2-
dc.type.docTypeArticle-
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Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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