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Submillimeter-resolution fMRI: Toward understanding local neural processing

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Title
Submillimeter-resolution fMRI: Toward understanding local neural processing
Author(s)
Fukuda, M; Poplawsky, AJ; S.-G. Kim
Publication Date
2016
Journal
PROGRESS IN BRAIN RESEARCH, v.225, no., pp.123 - 152
Publisher
ELSEVIER SCIENCE BV
Abstract
Functional magnetic resonance imaging (fMRI) measures the hemodynamic response to active neurons. The most prevailing fMRI contrast, blood oxygenation level-dependent (BOLD) contrast, specifically results from a complex interplay between oxygen metabolism, blood flow, and blood volume reactions. Therefore, because fMRI indirectly measures brain function, the spatial accuracy of these blood-borne signal changes to the true neuronal activity comes into question, especially at high resolutions. To better interpret the neural basis of fMRI, these properties have been studied in localized neural circuits of the brain using fMRI with blood flow, blood volume, and BOLD contrasts, as well as optical intrinsic signal imaging (OISI), which shares similar signal sources as fMRI. Here, we review how submillimeter-scale high-resolution fMRI and OISI in the visual cortex columnar and olfactory bulb laminar models have advanced our basic knowledge of the spatial localization of the individual hemodynamic signals and neurovascular coupling mechanisms. © 2016 Elsevier B.V. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/3318
ISSN
0079-6123
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Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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