IBS Publications Repository: Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)

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Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)

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Title: Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)

Subject: biodegradable polymers, ; drug delivery systems, ; poly(ethylene glycol), ; post-polymerization modification, ; ruthenium

Abstract: To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium- catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim