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Charles Surh
면역 미생물 공생 연구단
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Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy

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Title
Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy
Author(s)
Johnson, C. Bryce; Wrangle, John; Mehrotra, Shikhar; Li, Zihai; Paulos, Chrystal M.; Cole, David J.; Charles D. Surh; Rubinstein, Mark P.
Publication Date
2016-05
Journal
OncoImmunology, v.5, no.5, pp.e1122865 -
Abstract
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity. © 2016 Taylor & Francis Group, LLC
URI
https://pr.ibs.re.kr/handle/8788114/3172
ISSN
2162-402X
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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