IBS Publications RepositoryAcademy of Immunology and Microbiology(면역 미생물 공생 연구단)1. Journal Papers (저널논문)
Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy
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- Title
- Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy
- Author(s)
- Johnson, C. Bryce; Wrangle, John; Mehrotra, Shikhar; Li, Zihai; Paulos, Chrystal M.; Cole, David J.; Charles D. Surh; Rubinstein, Mark P.
- Subject
- Adoptive cellular therapy, ; CD8, ; IL-7, ; IL-7Ra, ; IL-15
- Publication Date
- 2016-05
- Journal
- ONCOIMMUNOLOGY, v.5, no.5, pp.e1122865
- Publisher
- TAYLOR & FRANCIS INC
- Abstract
- IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity. © 2016 Taylor & Francis Group, LLC
- ISSN
- 2162-4011
- Appears in Collections:
- Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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