Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Johnson, C. Bryce | - |
dc.contributor.author | Wrangle, John | - |
dc.contributor.author | Mehrotra, Shikhar | - |
dc.contributor.author | Li, Zihai | - |
dc.contributor.author | Paulos, Chrystal M. | - |
dc.contributor.author | Cole, David J. | - |
dc.contributor.author | Charles D. Surh | - |
dc.contributor.author | Rubinstein, Mark P. | - |
dc.date.available | 2017-01-06T02:05:13Z | - |
dc.date.created | 2017-01-05 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 2162-4011 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/3172 | - |
dc.description.abstract | IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity. © 2016 Taylor & Francis Group, LLC | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | Adoptive cellular therapy | - |
dc.subject | CD8 | - |
dc.subject | IL-7 | - |
dc.subject | IL-7Ra | - |
dc.subject | IL-15 | - |
dc.title | Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000379162200024 | - |
dc.identifier.scopusid | 2-s2.0-84964627091 | - |
dc.identifier.rimsid | 58159 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Charles D. Surh | - |
dc.identifier.doi | 10.1080/2162402X.2015.1122865 | - |
dc.identifier.bibliographicCitation | ONCOIMMUNOLOGY, v.5, no.5, pp.e1122865 | - |
dc.citation.title | ONCOIMMUNOLOGY | - |
dc.citation.volume | 5 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e1122865 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 2 | - |
dc.description.scptc | 2 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |