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Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy

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dc.contributor.authorJohnson, C. Bryce-
dc.contributor.authorWrangle, John-
dc.contributor.authorMehrotra, Shikhar-
dc.contributor.authorLi, Zihai-
dc.contributor.authorPaulos, Chrystal M.-
dc.contributor.authorCole, David J.-
dc.contributor.authorCharles D. Surh-
dc.contributor.authorRubinstein, Mark P.-
dc.date.available2017-01-06T02:05:13Z-
dc.date.created2017-01-05-
dc.date.issued2016-05-
dc.identifier.issn2162-4011-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3172-
dc.description.abstractIL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity. © 2016 Taylor & Francis Group, LLC-
dc.description.uri1-
dc.language영어-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectAdoptive cellular therapy-
dc.subjectCD8-
dc.subjectIL-7-
dc.subjectIL-7Ra-
dc.subjectIL-15-
dc.titleHarnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000379162200024-
dc.identifier.scopusid2-s2.0-84964627091-
dc.identifier.rimsid58159ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorCharles D. Surh-
dc.identifier.doi10.1080/2162402X.2015.1122865-
dc.identifier.bibliographicCitationONCOIMMUNOLOGY, v.5, no.5, pp.e1122865-
dc.citation.titleONCOIMMUNOLOGY-
dc.citation.volume5-
dc.citation.number5-
dc.citation.startPagee1122865-
dc.date.scptcdate2018-10-01-
dc.description.wostc2-
dc.description.scptc2-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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