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나노의학 연구단
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Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer

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Title
Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer
Author(s)
Mi Hyeon Cho; Seulmi Kim; Jae-Hyun Lee; Tae-Hyun Shin; Dongwon Yoo; Jinwoo Cheon
Publication Date
2016-12
Journal
NANO LETTERS, v.16, no.12, pp.7455 - 7460
Publisher
AMER CHEMICAL SOC
Abstract
Multidrug resistance (MDR) is a leading cause of failure in current chemotherapy treatment and constitutes a formidable challenge in therapeutics. Here, we demonstrate that a nanoscale magnetic tandem apoptosis trigger (m-TAT), which consists of a magnetic nanoparticle and chemodrug (e.g., doxorubicin), can completely remove MDR cancer cells in both in vitro and in vivo systems. m-TAT simultaneously activates extrinsic and intrinsic apoptosis signals in a synergistic fashion and downregulates the drug efflux pump (e.g., P-glycoprotein) which is one of the main causes of MDR. The tandem apoptosis strategy uses low level of chemodrug (in the nanomolar (nM) range) to eliminate MDR cancer cells. We further demonstrate that apoptosis of MDR cancer cells can be achieved in a spatially selective manner with single-cell level precision. Our study indicates that nanoscale tandem activation of convergent signaling pathways is a new platform concept to overcome MDR with high efficacy and specificity. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/3167
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
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