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A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

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Title
A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors
Author(s)
Jieon Lee; Il-Soo Park; Ginam Park; Cho, K; Park, HS; Dal-Hee Min
Publication Date
2016-10
Journal
CHEMICAL COMMUNICATIONS, v.52, no.81, pp.12112 - 12115
Publisher
ROYAL SOC CHEMISTRY
Abstract
We present a new platform for multiplexed protein kinase activity assay using TiO2 decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening. On the basis of the strong affinity of TiO2 for the phosphate group and the fluorescence quenching capability of GO, phosphorylation of substrates by protein kinases was quantitatively measured in a short time. © The Royal Society of Chemistry 2016
URI
https://pr.ibs.re.kr/handle/8788114/3071
ISSN
1359-7345
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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