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A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

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dc.contributor.authorJieon Lee-
dc.contributor.authorIl-Soo Park-
dc.contributor.authorGinam Park-
dc.contributor.authorCho, K-
dc.contributor.authorPark, HS-
dc.contributor.authorDal-Hee Min-
dc.date.available2016-12-22T01:43:49Z-
dc.date.created2016-11-23-
dc.date.issued2016-10-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3071-
dc.description.abstractWe present a new platform for multiplexed protein kinase activity assay using TiO2 decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening. On the basis of the strong affinity of TiO2 for the phosphate group and the fluorescence quenching capability of GO, phosphorylation of substrates by protein kinases was quantitatively measured in a short time. © The Royal Society of Chemistry 2016-
dc.description.uri1-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleA robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000385156700024-
dc.identifier.scopusid2-s2.0-84990060408-
dc.identifier.rimsid57702ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJieon Lee-
dc.contributor.affiliatedAuthorIl-Soo Park-
dc.contributor.affiliatedAuthorGinam Park-
dc.contributor.affiliatedAuthorDal-Hee Min-
dc.identifier.doi10.1039/c6cc05834e-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.52, no.81, pp.12112 - 12115-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume52-
dc.citation.number81-
dc.citation.startPage12112-
dc.citation.endPage12115-
dc.date.scptcdate2018-10-01-
dc.description.wostc3-
dc.description.scptc3-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusGRAPHENE OXIDE-
dc.subject.keywordPlusMASS-SPECTROMETRY-
dc.subject.keywordPlusPHOSPHORYLATION PROTECTION-
dc.subject.keywordPlusHYBRID MATERIALS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusPHOSPHOPROTEOME-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusBIOMOLECULES-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusBIOSENSOR-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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