The ability to solve elementary logic tasks in mice with the knockout of sodium–calcium exchanger gene 2 (NCX2)

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Title
The ability to solve elementary logic tasks in mice with the knockout of sodium–calcium exchanger gene 2 (NCX2)
Author(s)
Poletaeva I.I.; Perepelkina O.V.; Boyarshinova O.S.; Golibrodo V.A.; Lilp I.G.; Lipp H.-P.; Hee Sup Shin
Publication Date
2016-07
Journal
DOKLADY BIOLOGICAL SCIENCES, v.469, no.1, pp.159 - 162
Publisher
Maik Nauka/Interperiodica Publishing
Abstract
Mice with a knockout of the sodium–calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of the stimulus movement and the “puzzle-box” test for the capacity to find a hidden route to safe environment, which were based on food and aversive motivations, respectively. In both tests, the success of task solution was based on the animal’s ability to use the object’s “permanence” rule (according to J. Piaget). The data confirm that the knockout of this gene, which is accompanied by modulation of the temporal pattern of calcium membrane flux, also induces changes in mouse CNS plasticity. © 2016, Pleiades Publishing, Ltd
URI
https://pr.ibs.re.kr/handle/8788114/2999
ISSN
0012-4966
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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