BROWSE

Related Scientist

Researcher

신창식
첨단연성물질 연구단
more info

Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells

Cited 4 time in webofscience Cited 0 time in scopus
172 Viewed 47 Downloaded
Title
Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells
Author(s)
Hyundoo Hwang; Changsik Shin; Juhee Park; Enoch Kang; Bongseo Choi; Jae-A Han; Yoonkyung Do; Seongho Ryu; Yoon-Kyoung Cho
Publication Date
2016-07
Journal
SCIENTIFIC REPORTS, v.6, no., pp.30207 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Breast cancer remains as a challenging disease with high mortality in women. Increasing evidence points the importance of understanding a crosstalk between breast cancers and immune cells, but little is known about the effect of breast cancer-derived factors on the migratory properties of dendritic cells (DCs) and their consequent capability in inducing T cell immune responses. Utilizing a unique 3D microfluidic device, we here showed that breast cancers (MCF-7, MDA-MB-231, MDA-MB-436 and SK-BR-3)-derived soluble factors increase the migration of DCs toward CCL19. The enhanced migration of DCs was mainly mediated via the highly activated JNK/c-Jun signaling pathway, increasing their directional persistence, while the velocity of DCs was not influenced, particularly when they were co-cultured with triple negative breast cancer cells (TNBCs or MDA-MB-231 and MDA-MB-436). The DCs up-regulated inflammatory cytokines IL-1β and IL-6 and induced T cells more proliferative and resistant against activation-induced cell death (AICD), which secret high levels of inflammatory cytokines IL-1β, IL-6 and IFN-Î 3. This study demonstrated new possible evasion strategy of TNBCs utilizing their soluble factors that exploit the directionality of DCs toward chemokine responses, leading to the building of inflammatory milieu which may support their own growth. © The Author(s) 2016
URI
http://pr.ibs.re.kr/handle/8788114/2998
DOI
10.1038/srep30207
ISSN
2045-2322
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse