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Kristiana Kandere-Grzybowska
첨단연성물질 연구단
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Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

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Title
Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
Author(s)
Pramod P. Pillai; Bartlomiej Kowalczyk; Kristiana Kandere-Grzybowska; Magdalena Borkowska; Bartosz A. Grzybowski
Publication Date
2016-07
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.30, pp.8610 - 8614
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro) molecular level. (c) 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/2995
ISSN
1433-7851
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
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