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박선영
첨단연성물질 연구단
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Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications

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Title
Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
Author(s)
Jung Seung Nam; Myeong-Gyun Kang; Juhye Kang; Sun-Young Park; Shin Jung C. Lee; Hyun-Tak Kim; Jeong Kon SeoSeo J.K.; Oh-Hoon Kwon; Mi Hee Lim; Hyun-Woo Rhee; Tae-Hyuk Kwon
Publication Date
2016-08
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.138, no.34, pp.10968 - 10977
Publisher
AMER CHEMICAL SOC
Abstract
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (1O2) and superoxide radical (O2 •-) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct involvement in photodynamic therapy (PDT) have not been revealed. Herein, we report Ir(III) complexes designed for ROS generation through a rational strategy to investigate protein modifications by ROS. The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation (≤ 1 J cm-2) because of the relatively high 1O2 quantum yield (> 0.78), even with two-photon activation. Furthermore, two types of protein modifications (protein oxidation and photo-cross-linking) involved in PDT were characterized by mass spectrometry. These modifications were generated primarily in the endoplasmic reticulum and mitochondria, producing a significant effect for cancer cell death. Consequently, we present a plausible biologically applicable PDT modality that utilizes rationally designed photoactivatable Ir(III) complexes. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2987
ISSN
0002-7863
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
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