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면역미생물공생연구단
면역 미생물 공생 연구단
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Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

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Title
Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
Author(s)
Sugawara, R; Eun-Jung Lee; Min Seong Jang; Eun-Ji Jeun; Chun-Pyo Hong; Jung-Hwan Kim; Park, A; Chang Ho Yun; Sung-Wook Hong; Kim, YM; Seoh, JY; Jung, Y; Charles D. Surh; Miyasaka, M; Bo-Gie Yang; Myoung Ho Jang
Publication Date
2016-04
Journal
JOURNAL OF EXPERIMENTAL MEDICINE, v.213, no.4, pp.555 - 567
Publisher
ROCKEFELLER UNIV PRESS
Abstract
Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra © 2016 Sugawara et al.
URI
http://pr.ibs.re.kr/handle/8788114/2826
DOI
10.1084/jem.20141388
ISSN
0022-1007
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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