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Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging

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Title
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
Author(s)
Wang T.; Jang W.H.; Lee S.; Yoon C.J.; Lee J.H.; Kim B.; Hwang S.; Hong C.-P.; Yoon Y.; Lee G.; Le V.-H.; Bok S.; Ahn G.-O.; Lee J.; Gho Y.S.; Chung E.; Kim S.; Myoung Ho Jang; Myung S.-J.; Kim M.J.; So P.T.C.; Kim K.H.
Publication Date
2016-06
Journal
SCIENTIFIC REPORTS, v.6, no., pp.27142 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence
URI
http://pr.ibs.re.kr/handle/8788114/2816
DOI
10.1038/srep27142
ISSN
2045-2322
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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