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Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging

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dc.contributor.authorWang T.-
dc.contributor.authorJang W.H.-
dc.contributor.authorLee S.-
dc.contributor.authorYoon C.J.-
dc.contributor.authorLee J.H.-
dc.contributor.authorKim B.-
dc.contributor.authorHwang S.-
dc.contributor.authorHong C.-P.-
dc.contributor.authorYoon Y.-
dc.contributor.authorLee G.-
dc.contributor.authorLe V.-H.-
dc.contributor.authorBok S.-
dc.contributor.authorAhn G.-O.-
dc.contributor.authorLee J.-
dc.contributor.authorGho Y.S.-
dc.contributor.authorChung E.-
dc.contributor.authorKim S.-
dc.contributor.authorMyoung Ho Jang-
dc.contributor.authorMyung S.-J.-
dc.contributor.authorKim M.J.-
dc.contributor.authorSo P.T.C.-
dc.contributor.authorKim K.H.-
dc.date.accessioned2016-10-06T06:35:48Z-
dc.date.available2016-10-06T06:35:48Z-
dc.date.created2016-07-18-
dc.date.issued2016-06-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2816-
dc.description.abstractMultiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleMoxifloxacin: Clinically compatible contrast agent for multiphoton imaging-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000377680900001-
dc.identifier.scopusid2-s2.0-84974555516-
dc.identifier.rimsid56128-
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorMyoung Ho Jang-
dc.identifier.doi10.1038/srep27142-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.6, pp.27142-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume6-
dc.citation.startPage27142-
dc.date.scptcdate2018-10-01-
dc.description.wostc4-
dc.description.scptc4-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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