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Choi, Suyeon
시냅스 뇌질환 연구단
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SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion

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Title
SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion
Author(s)
Eunkyung Lie; Ji Seung Ko; Su-Yeon Choi; Junyeop Daniel Roh; Yi Sul Cho; Ran Noh; Doyoun Kim; Yan Li; Hyeyeon Kang; Tae-Yong Choi; Jungyoung Nam; Won Mah; Dongmin Lee; Seung-Gyu Lee; Ho Min Kim; Hyun Kim; Se-Young Choi; Ji Won Um; Myoung-Goo Kang; Yong Chul Bae; Jaewon Ko; Eunjoon Kim
Publication Date
2016-08
Journal
NATURE COMMUNICATIONS, v.7, pp.12328
Publisher
NATURE PUBLISHING GROUP
Abstract
Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4 mice (Salm3, Salm4) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3-LAR adhesion. © The Author(s) 2016
URI
https://pr.ibs.re.kr/handle/8788114/2755
DOI
10.1038/ncomms12328
ISSN
2041-1723
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
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