SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion

DC Field Value Language
dc.contributor.authorEunkyung Lie-
dc.contributor.authorJi Seung Ko-
dc.contributor.authorSu-Yeon Choi-
dc.contributor.authorJunyeop Daniel Roh-
dc.contributor.authorYi Sul Cho-
dc.contributor.authorRan Noh-
dc.contributor.authorDoyoun Kim-
dc.contributor.authorYan Li-
dc.contributor.authorHyeyeon Kang-
dc.contributor.authorTae-Yong Choi-
dc.contributor.authorJungyoung Nam-
dc.contributor.authorWon Mah-
dc.contributor.authorDongmin Lee-
dc.contributor.authorSeung-Gyu Lee-
dc.contributor.authorHo Min Kim-
dc.contributor.authorHyun Kim-
dc.contributor.authorSe-Young Choi-
dc.contributor.authorJi Won Um-
dc.contributor.authorMyoung-Goo Kang-
dc.contributor.authorYong Chul Bae-
dc.contributor.authorJaewon Ko-
dc.contributor.authorEunjoon Kim-
dc.date.available2016-09-01T02:34:08Z-
dc.date.created2016-08-19-
dc.date.issued2016-08-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2755-
dc.description.abstractSynaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4 mice (Salm3, Salm4) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3-LAR adhesion. © The Author(s) 2016-
dc.languageENG-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleSALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000380857200001-
dc.identifier.scopusid2-s2.0-84982672436-
dc.description.wostc10-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.contributor.affiliatedAuthorSu-Yeon Choi-
dc.contributor.affiliatedAuthorJunyeop Daniel Roh-
dc.contributor.affiliatedAuthorRan Noh-
dc.contributor.affiliatedAuthorDoyoun Kim-
dc.contributor.affiliatedAuthorYan Li-
dc.contributor.affiliatedAuthorHo Min Kim-
dc.contributor.affiliatedAuthorMyoung-Goo Kang-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.7, no., pp.12328 --
dc.description.scptc10-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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