Water Structure at the Lipid Multibilayer Surface: Anionic Versus Cationic Head Group Effects

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Title
Water Structure at the Lipid Multibilayer Surface: Anionic Versus Cationic Head Group Effects
Author(s)
Achintya Kundu; Kyungwon Kwak; Minhaeng Cho
Publication Date
2016-06
Journal
JOURNAL OF PHYSICAL CHEMISTRY B, v.120, no.22, pp.5002 - 5007
Publisher
AMER CHEMICAL SOC
Abstract
Membrane water interface is a potential reaction site for many biochemical reactions. Therefore, a molecular level understanding of water structure and dynamics that strongly depend on the chemical structure of lipid is prerequisite for elucidating the role of water in biological reactions on membrane surface. Recently, we carried out femtosecond infrared pump probe studies of water structure and dynamics at multibilayer surfaces of zwitterionic phosphatidylcholine-analogue lipid (J. Phys. Chem. Lett. 2016, 7, 741). Here, to further elucidate the anionic and cationic headgroup effects on water, we study vibrational dynamics of water on lipid multibilayers formed by anionic phospho-glycerol lipid molecules as well as by cationic choline-derivatized lipid molecules. We observed two significantly different vibrational lifetime components (very fast 0.5 ps and slow 1.9 ps) of the OD stretch mode of HOD molecules at the negatively charged phospho-lipid multibilayer whereas only one vibrational lifetime component (1.6 ps) was observed at the positively charged choline-derivatized lipid multibilayer. From the detailed analyses about the vibrational energy and rotational relaxations of HOD molecules in lipid multibilayers composed of anionic lipid with phosphate and cationic lipid without phosphate, the role of phosphate group in structuring water molecules at phospholipid membrane interface is revealed. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2749
ISSN
1520-6106
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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