Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm

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Title
Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm
Author(s)
Gireesh Gangadharan; Jonghan Shin; Seong-Wook Kim; Angela Kim; Afshin Paydar; Duk-Soo Kim; Taisuke Miyazaki; Masahiko Watanabe; Yuchio Yanagawa; Jinhyun Kim; yeon-Soo Kim; Daesoo Kim; Hee-Sup Shin
Publication Date
2016-06
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.23, pp.6550 - 6555
Publisher
NATL ACAD SCIENCES
Abstract
Contributed by Hee-Sup Shin, April 20, 2016 (sent for review February 16, 2016; reviewed by Jan Born, György Buzsáki, and Alcino J. Silva) Exploratory drive is one of the most fundamental emotions, of all organisms, that are evoked by novelty stimulation. Exploratory behavior plays a fundamental role in motivation, learning, and well-being of organisms. Diverse exploratory behaviors have been described, although their heterogeneity is not certain because of the lack of solid experimental evidence for their distinction. Here we present results demonstrating that different neural mechanisms underlie different exploratory behaviors. Localized Cav3.1 knockdown in the medial septum (MS) selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhancedobject exploration as well as open-field exploration. In MS knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in KO mice. This selective effect was accompanied by markedly increased excitability of septo-hippocampal GABAergic projection neurons in the MS lacking T-type Ca2+ channels. Furthermore, optogenetic activation of the septo-hippocampal GABAergic pathway in WT mice also selectively enhanced object exploration behavior and type 2 theta rhythm, whereas inhibition of the same pathway decreased the behavior and the rhythm. These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca2+ channels in the medial septal GABAergic projection neurons in this behavior.
URI
https://pr.ibs.re.kr/handle/8788114/2600
ISSN
0027-8424
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
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