Ultrafast Structural Fluctuations of Myoglobin-Bound Thiocyanate and Selenocyanate Ions Measured with Two-Dimensional Infrared Photon Echo Spectroscopy

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Title
Ultrafast Structural Fluctuations of Myoglobin-Bound Thiocyanate and Selenocyanate Ions Measured with Two-Dimensional Infrared Photon Echo Spectroscopy
Author(s)
Michal Maj; Kwak, K; Minhaeng Cho
Publication Date
2016-03
Journal
CHEMPHYSCHEM, v.17, no.6, pp.921 - 921
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Structural dynamics within the distal cavity of myoglobin protein is investigated using 2D-IR and IR pump–probe spectroscopy of the N≡C stretch modes of heme-bound thiocyanate and selenocyanate ions. Although myoglobin-bound thiocyanate group shows a doublet in its IR absorption spectrum, no cross peaks originating from chemical exchange between the two components are observed in the time-resolved 2D IR spectra within the experimental time window. Frequency–frequency correlation functions of the two studied anionic ligands are obtained by means of a few different analysis approaches; these functions were then used to elucidate the differences in structural fluctuation around ligand, ligand–protein interactions, and the degree of structural heterogeneity within the hydrophobic pocket of these myoglobin complexes.
URI
https://pr.ibs.re.kr/handle/8788114/2589
ISSN
1439-4235
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
Files in This Item:
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