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Indranil Roy
복잡계 자기조립 연구단
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A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic-Resistant Bacteria

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Title
A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic-Resistant Bacteria
Author(s)
Indranil Roy; Dinesh Shetty; Hota, R; Kangkyun Back; Kim, J; Kim, C; Sandro Kappert; Kimoon Kim
Publication Date
2015-12
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.54, no.50, pp.15152 - 15155
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Developing a material that can combat antibioticresistant bacteria, a major global health threat, is an urgent requirement. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic-resistant bacteria in a single treatment with more than 99% efficiency, even with a dose as low as 4.2 Jcm(-2) and a loading concentration of 10 nM. The positively charged nanosphere shell composed of covalently linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably because of their enhanced water dispersibility, higher efficiency of singletoxygen generation, and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in photoacoustic imaging of bacteria in vivo (c) 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/2465
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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복잡계 Roy_et_al-2015-Angewandte_Chemie_International_Edition.pdfDownload

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