BROWSE

Related Scientist

Researcher

조윤경
첨단연성물질 연구단
more info

Intrinsic features of the CD8α- dendritic cell subset in inducing functional T follicular helper cells

Cited 3 time in webofscience Cited 0 time in scopus
426 Viewed 31 Downloaded
Title
Intrinsic features of the CD8α- dendritic cell subset in inducing functional T follicular helper cells
Author(s)
Shin C.; Han J.-A.; Choi B.; Yoon-Kyoung Cho; Do Y.; Ryu S.
Publication Date
2016-04
Journal
IMMUNOLOGY LETTERS, v.172, no., pp.21 - 28
Publisher
ELSEVIER SCIENCE BV
Abstract
T follicular helper (Tfh) cells, a true B cell helper, have a critical role in enhancing humoral immune responses. However, the initial differentiation of Tfh cells by dendritic cells (DCs), the most potent antigen presenting cells, has not been clearly understood, particularly in the knowledge of the two major conventional dendritic cell subsets, CD8α+ DCs or CD8α- DCs. Here we demonstrated that the localization of CD8α- DCs in the marginal zone (MZ) bridging channels is closely associated with the induction of CXCR5+CCR7low Tfh cells. We also showed that the major source of IL-6 for inducing Tfh cells is provided from the activated CD4+ T cells induced by CD8α- DCs, and IL-6 directly secreted from the DC subsets seems minor. CD8α- DCs were superior in inducing functional Tfh cells over other antigen presenting cells including B cells. We here observed the unknown intrinsic features of the DC subsets, suggesting the potential of utilizing the CD8α- DC subset as therapeutic vaccine for the regulation of humoral immune responses. © 2016 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/2448
ISSN
0165-2478
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
Intrinsic features of the CD8α- dendritic cell subset in inducing functional T follicular helper cells.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse