BROWSE

Related Scientist

Researcher

김광순
면역 미생물 공생 연구단
more info

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine Highly Cited Paper

Cited 90 time in webofscience Cited 0 time in scopus
1,406 Viewed 392 Downloaded
Title
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
Author(s)
Kwang Soon Kim; Sung-Wook Hong; Daehee Han; Jaeu Yi; Jisun Jung; Bo-Gie Yang; Jun Young Lee; Minji Lee; Charles D. Surh
Publication Date
2016-02
Journal
SCIENCE, v.351, no.6275, pp.858 - 863
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Dietary antigens are normally rendered non-immunogenic through a poorly understood “oral tolerance” mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTregs). While orally introducing nominal protein antigens induces such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions is unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrate that the vast majority of the small intestinal pTreg cells under normal conditions is induced by dietary antigens from solid foods. Moreover, these pTreg cells have a limited lifespan, are distinguishable from microbiota-induced pTreg cells, and repress underlying strong immunity to ingested protein antigens.
URI
https://pr.ibs.re.kr/handle/8788114/2405
ISSN
0036-8075
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
aac5560_ArticleContent_figures.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse