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Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestineHighly Cited Paper

DC Field Value Language
dc.contributor.authorKwang Soon Kim-
dc.contributor.authorSung-Wook Hong-
dc.contributor.authorDaehee Han-
dc.contributor.authorJaeu Yi-
dc.contributor.authorJisun Jung-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorJun Young Lee-
dc.contributor.authorMinji Lee-
dc.contributor.authorCharles D. Surh-
dc.date.available2016-03-07T06:36:33Z-
dc.date.created2016-03-07-
dc.date.issued2016-02-
dc.identifier.issn0036-8075-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2405-
dc.description.abstractDietary antigens are normally rendered non-immunogenic through a poorly understood “oral tolerance” mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTregs). While orally introducing nominal protein antigens induces such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions is unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrate that the vast majority of the small intestinal pTreg cells under normal conditions is induced by dietary antigens from solid foods. Moreover, these pTreg cells have a limited lifespan, are distinguishable from microbiota-induced pTreg cells, and repress underlying strong immunity to ingested protein antigens.-
dc.description.uri1-
dc.language영어-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleDietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000370325700044-
dc.identifier.scopusid2-s2.0-84958910139-
dc.identifier.rimsid22499ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorKwang Soon Kim-
dc.contributor.affiliatedAuthorSung-Wook Hong-
dc.contributor.affiliatedAuthorDaehee Han-
dc.contributor.affiliatedAuthorJaeu Yi-
dc.contributor.affiliatedAuthorJisun Jung-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.contributor.affiliatedAuthorJun Young Lee-
dc.contributor.affiliatedAuthorMinji Lee-
dc.contributor.affiliatedAuthorCharles D. Surh-
dc.identifier.doi10.1126/science.aac5560-
dc.identifier.bibliographicCitationSCIENCE, v.351, no.6275, pp.858 - 863-
dc.citation.titleSCIENCE-
dc.citation.volume351-
dc.citation.number6275-
dc.citation.startPage858-
dc.citation.endPage863-
dc.date.scptcdate2018-10-01-
dc.description.wostc90-
dc.description.scptc90-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusORAL TOLERANCE-
dc.subject.keywordPlusRETINOIC-ACID-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusREG-CELLS-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusDIVERSITY-
dc.subject.keywordPlusABSENCE-
dc.subject.keywordPlusMICE-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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