BROWSE

Related Scientist

Researcher

노준호
복잡계 자기조립 연구단
more info

Charge screening in RNA: an integral route for dynamical enhancements

Cited 2 time in webofscience Cited 0 time in scopus
245 Viewed 3 Downloaded
Title
Charge screening in RNA: an integral route for dynamical enhancements
Author(s)
Joon Ho Roh; Tyagi, M.; Pulakesh Aich; Kimoon Kim; Briber, R.M.; Woodson, S.A.
Publication Date
2015-09
Journal
SOFT MATTER, v.11, no.45, pp.8741 - 8745
Publisher
ROYAL SOC CHEMISTRY
Abstract
Electrostatic interactions of RNA are at the center of determining the dynamical flexibility and structural stability. By analysing neutron scattering spectroscopy, we show that fast dynamics of hydrated tRNA on ps to ns timescales increases with stronger charge screening, while its structural stability either increases or remains largely unchanged. An unprecedented electrostatic threshold for the onset of additional flexibility is induced from the correlation between the charge-screening density of counterions and the promoted dynamical properties. The results demonstrate that the enhanced dynamical flexibility of tRNA originates from local conformational relaxation coupled with stabilized charge screening rather than governed by fluctuation of hydrated counterions. The present study casts light on the specificity of electrostatic interactions in the thermodynamic balance between the dynamical flexibility and structural stability of RNA. © The Royal Society of Chemistry
URI
https://pr.ibs.re.kr/handle/8788114/2364
ISSN
1744-683X
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
Charge screening in RNA.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse