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Polymeric biomaterials for the delivery of platinum-based anticancer drugs

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Title
Polymeric biomaterials for the delivery of platinum-based anticancer drugs
Author(s)
Kim, J; Swapan Pramanick; Duhwan Lee; Park, H; Won Jong Kim
Publication Date
2015-07
Journal
BIOMATERIALS SCIENCE, v.3, no.7, pp.1002 - 1017
Abstract
Since cisplatin, cis-diamminedichloroplatinum(II), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems
URI
https://pr.ibs.re.kr/handle/8788114/2174
ISSN
2047-4830
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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