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Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

Cited 15 time in webofscience Cited 16 time in scopus
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Title
Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses
Author(s)
Jung-Eun Kim; Chang Suk Chae; Gi-Cheon Kim; Won Hwang; Ji-sun Hwang; Sung-Min Hwang; Kim Y.; Ahn Y.-T.; Park S.-G.; Jun C.-D.; Dipayan Rudra; Sin-Hyeog Im
Subject
Cytokine, Inflammation, Immune modulation, Probiotics, Rheumatoid arthritis
Publication Date
2015-02
Journal
JOURNAL OF FUNCTIONAL FOODS, v.13, pp.350 - 362
Publisher
ELSEVIER SCIENCE BV
Abstract
Although probiotics could confer health benefits to host physiology, their efficacy is strain specific. To identify anti-inflammatory probiotics, an ex vivo screening system was developed, and validated effector functions of selected candidates using experimental rheumatoid arthritis as an in vivo model. Lactobacillus helveticus HY7801 was selected as the best candidate. Oral administration of L. helveticus HY7801 prevented the development of collageninduced experimental arthritis, and diminished disease progression and severity by reducing antigen specific IgG levels and inflammatory immune response. Administration of L. helveticus HY7801 may induce regulatory CD11c+ dendritic cells, which in turn induce a phenotypic alteration of immune cells by reducing pro-inflammatory cytokines (TNF-α, IFN-γ, and IL- 17A) while enhancing anti-inflammatory cytokine (IL-10) by CD4+ T cells. This study suggests that screening of probiotic strains based on the IL-10highIL-12low selection criterion may be applicable to identify anti-inflammatory probiotics as an efficacious food for treating inflammatory immune responses including rheumatoid arthritis. © 2015 Elsevier Ltd. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/2127
DOI
10.1016/j.jff.2015.01.002
ISSN
1756-4646
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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