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면역미생물공생연구단
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Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

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dc.contributor.authorJung-Eun Kim-
dc.contributor.authorChang Suk Chae-
dc.contributor.authorGi-Cheon Kim-
dc.contributor.authorWon Hwang-
dc.contributor.authorJi-sun Hwang-
dc.contributor.authorSung-Min Hwang-
dc.contributor.authorKim Y.-
dc.contributor.authorAhn Y.-T.-
dc.contributor.authorPark S.-G.-
dc.contributor.authorJun C.-D.-
dc.contributor.authorDipayan Rudra-
dc.contributor.authorSin-Hyeog Im-
dc.date.available2016-01-07T09:15:25Z-
dc.date.created2015-03-02-
dc.date.issued2015-02-
dc.identifier.issn1756-4646-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2127-
dc.description.abstractAlthough probiotics could confer health benefits to host physiology, their efficacy is strain specific. To identify anti-inflammatory probiotics, an ex vivo screening system was developed, and validated effector functions of selected candidates using experimental rheumatoid arthritis as an in vivo model. Lactobacillus helveticus HY7801 was selected as the best candidate. Oral administration of L. helveticus HY7801 prevented the development of collageninduced experimental arthritis, and diminished disease progression and severity by reducing antigen specific IgG levels and inflammatory immune response. Administration of L. helveticus HY7801 may induce regulatory CD11c+ dendritic cells, which in turn induce a phenotypic alteration of immune cells by reducing pro-inflammatory cytokines (TNF-α, IFN-γ, and IL- 17A) while enhancing anti-inflammatory cytokine (IL-10) by CD4+ T cells. This study suggests that screening of probiotic strains based on the IL-10highIL-12low selection criterion may be applicable to identify anti-inflammatory probiotics as an efficacious food for treating inflammatory immune responses including rheumatoid arthritis. © 2015 Elsevier Ltd. All rights reserved.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectCytokine, Inflammation, Immune modulation, Probiotics, Rheumatoid arthritis-
dc.titleLactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000350612800035-
dc.identifier.scopusid2-s2.0-84922562059-
dc.identifier.rimsid17782ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJung-Eun Kim-
dc.contributor.affiliatedAuthorChang Suk Chae-
dc.contributor.affiliatedAuthorGi-Cheon Kim-
dc.contributor.affiliatedAuthorWon Hwang-
dc.contributor.affiliatedAuthorJi-sun Hwang-
dc.contributor.affiliatedAuthorSung-Min Hwang-
dc.contributor.affiliatedAuthorDipayan Rudra-
dc.contributor.affiliatedAuthorSin-Hyeog Im-
dc.identifier.doi10.1016/j.jff.2015.01.002-
dc.identifier.bibliographicCitationJOURNAL OF FUNCTIONAL FOODS, v.13, pp.350 - 362-
dc.citation.titleJOURNAL OF FUNCTIONAL FOODS-
dc.citation.volume13-
dc.citation.startPage350-
dc.citation.endPage362-
dc.date.scptcdate2018-10-01-
dc.description.wostc7-
dc.description.scptc7-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusCOLLAGEN-INDUCED ARTHRITIS-
dc.subject.keywordPlusEXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS-
dc.subject.keywordPlusGUT MICROBIOTA-
dc.subject.keywordPlusMETABOLIC INTERACTIONS-
dc.subject.keywordPlusINTESTINAL MICROBIOTA-
dc.subject.keywordPlusPROBIOTIC MIXTURE-
dc.subject.keywordPlusIMMUNE-RESPONSE-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusINNATE IMMUNITY-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordAuthorCytokine-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorImmune modulation-
dc.subject.keywordAuthorProbiotics-
dc.subject.keywordAuthorRheumatoid arthritis-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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