BROWSE

Related Scientist

nanomat's photo.

nanomat
나노입자연구단
more info

ITEM VIEW & DOWNLOAD

Glioblastoma treated with concurrent radiation therapy and temozolomide chemotherapy: Differentiation of true progression from pseudoprogression with quantitative dynamic contrast-enhanced MR Imaging

DC Field Value Language
dc.contributor.authorYun T.J.-
dc.contributor.authorPark C.-K.-
dc.contributor.authorKim T.M.-
dc.contributor.authorLee S.-H.-
dc.contributor.authorKim J.-H.-
dc.contributor.authorSohn C.-H.-
dc.contributor.authorPark S.-H.-
dc.contributor.authorKim I.H.-
dc.contributor.authorSeung Hong Choi-
dc.date.available2016-01-07T09:14:38Z-
dc.date.created2015-04-06-
dc.date.issued2015-03-
dc.identifier.issn0033-8419-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2080-
dc.description.abstractPurpose: To explore the role of dynamic contrast material-enhanced magnetic resonance (MR) imaging in the differentiation of true progression from pseudoprogression in patients with glioblastoma on the basis of findings in entirely newly developed or enlarged enhancing lesions after concurrent radiation therapy and chemotherapy with temozolomide and to evaluate the diagnostic performance of the quantitative pharmacokinetic parameters obtained at dynamic contrast-enhanced MR imaging, such as the volume transfer constant (Ktrans), the extravascular extracellular space per unit volume of tissue(ve), and the blood plasma volume per unit volume of tissue(vp). Materials and Methods: This prospective study had institutional review board approval; written informed consent was obtained from all patients. Thirty-three patients with histopathologically proven glioblastoma who had undergone concurrent radiation therapy and chemotherapy with temozolomide were included. Dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters, including Ktrans, ve, and vp, were calculated for newly developed or enlarged enhancing lesions. Pharmacokinetic parameters were compared between the true progression (n = 17) and pseudoprogression (n = 16) groups by using unpaired t tests and then multivariable analysis.. Results: The mean Ktrans and ve were higher in the true progression group than in the pseudoprogression group (mean Ktrans, 0.44 min-1 ± 0.25 [standard deviation] and 0.23 min21 ± 0.10 for true progression and pseudoprogression groups, respectively, P = .004; and mean ve, 1.26 ± 0.78 and 0.75 ± 0.49 for true progression and pseudoprogression groups, respectively, P = .034). Multivariable analysis showed that mean Ktrans was the only independently differentiating variable (P = .004).. © RSNA, 2014-
dc.description.uri1-
dc.language영어-
dc.publisherRADIOLOGICAL SOC NORTH AMERICA-
dc.titleGlioblastoma treated with concurrent radiation therapy and temozolomide chemotherapy: Differentiation of true progression from pseudoprogression with quantitative dynamic contrast-enhanced MR Imaging-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000349990500022-
dc.identifier.scopusid2-s2.0-84924301211-
dc.identifier.rimsid19256-
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.identifier.doi10.1148/radiol.14132632-
dc.identifier.bibliographicCitationRADIOLOGY, v.274, no.3, pp.830 - 840-
dc.citation.titleRADIOLOGY-
dc.citation.volume274-
dc.citation.number3-
dc.citation.startPage830-
dc.citation.endPage840-
dc.date.scptcdate2018-10-01-
dc.description.wostc28-
dc.description.scptc31-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
radiol.14132632.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse