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분자활성 촉매반응 연구단
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Rh(III) and Ru(II)-catalyzed site-selective C-H alkynylation of quinolones

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Title
Rh(III) and Ru(II)-catalyzed site-selective C-H alkynylation of quinolones
Author(s)
Dahye Kang; Sungwoo Hong
Publication Date
2015-04
Journal
ORGANIC LETTERS, v.17, no.8, pp.1938 - 1941
Publisher
AMER CHEMICAL SOC
Abstract
C2- and C5-alkynylated quinolone scaffolds are core structures of numerous biologically active molecules. Utilizing TIPS-EBX as an alkynylating agent, we have developed an efficient and site-selective C5 alkynylation of 4-quinolones that is directed by the weakly coordinating carbonyl group. In addition, Ru(II) catalyzed C2-selective alkynylation was successfully realized via N-pyrimidyl group-directed cross-couplings to access valuable C2-alkynylated 4-quinolones. This strategy provides direct access to the C2 or C5 alkynylated 4-quinolones. Furthermore, the reaction was applied to isoquinolones for C3-selective alkynylation. © 2015 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2067
ISSN
1523-7060
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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