Rh(III) and Ru(II)-catalyzed site-selective C-H alkynylation of quinolones
DC Field | Value | Language |
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dc.contributor.author | Dahye Kang | - |
dc.contributor.author | Sungwoo Hong | - |
dc.date.available | 2016-01-07T09:14:25Z | - |
dc.date.created | 2015-05-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/2067 | - |
dc.description.abstract | C2- and C5-alkynylated quinolone scaffolds are core structures of numerous biologically active molecules. Utilizing TIPS-EBX as an alkynylating agent, we have developed an efficient and site-selective C5 alkynylation of 4-quinolones that is directed by the weakly coordinating carbonyl group. In addition, Ru(II) catalyzed C2-selective alkynylation was successfully realized via N-pyrimidyl group-directed cross-couplings to access valuable C2-alkynylated 4-quinolones. This strategy provides direct access to the C2 or C5 alkynylated 4-quinolones. Furthermore, the reaction was applied to isoquinolones for C3-selective alkynylation. © 2015 American Chemical Society | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Rh(III) and Ru(II)-catalyzed site-selective C-H alkynylation of quinolones | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000353314800031 | - |
dc.identifier.scopusid | 2-s2.0-84928041937 | - |
dc.identifier.rimsid | 19609 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Dahye Kang | - |
dc.contributor.affiliatedAuthor | Sungwoo Hong | - |
dc.identifier.doi | 10.1021/acs.orglett.5b00641 | - |
dc.identifier.bibliographicCitation | ORGANIC LETTERS, v.17, no.8, pp.1938 - 1941 | - |
dc.citation.title | ORGANIC LETTERS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1938 | - |
dc.citation.endPage | 1941 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 45 | - |
dc.description.scptc | 44 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |