β-Isocyanoalanine as an IR probe: comparison of vibrational dynamics between isonitrile and nitrile-derivatized IR probes

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Title
β-Isocyanoalanine as an IR probe: comparison of vibrational dynamics between isonitrile and nitrile-derivatized IR probes
Author(s)
Michał Maj; Changwoo Ahn; Dorota Kossowska; Kwanghee Park; Kyungwon Kwak; Hogyu Han; Minhaeng Cho
Publication Date
2015-05
Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, v.17, no.17, pp.11770 - 11778
Publisher
ROYAL SOC CHEMISTRY
Abstract
An infrared (IR) probe based on isonitrile (NC)-derivatized alanine 1 was synthesized and the vibrational properties of its NC stretching mode were investigated using FTIR and femtosecond IR pump-probe spectroscopy. It is found that the NC stretching mode is very sensitive to the hydrogen-bonding ability of solvent molecules. Moreover, its transition dipole strength is larger than that of nitrile (CN) in nitrile-derivatized IR probe 2. The vibrational lifetime of the NC stretching mode is found to be 5.5 ± 0.2 ps in both D2O and DMF solvents, which is several times longer than that of the azido (N3) stretching mode in azido-derivatized IR probe 3. Altogether these properties suggest that the NC group can be a very promising sensing moiety of IR probes for studying the solvation structure and dynamics of biomolecules. This journal is © the Owner Societies 2015
URI
https://pr.ibs.re.kr/handle/8788114/2020
ISSN
1463-9076
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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